Newest publications from the lab:
Sangha S*, Fitzgerald JM (2024). Translational Approaches to the Neurobiological Study of Conditional Discrimination and Inhibition: Implications for Psychiatric Disease. Behavioral Neuroscience, Advance online publication. https://dx.doi.org/10.1037/bne0000594.
Krueger JN, Patel NN, Shim K, Ng K, Sangha S* (2024). Conditioned inhibition of fear and reward in male and female rats. Neurobiology of Learning & Memory 208: 107881.
Ng K, Pollock M, Escobedo A, Bachman B, Miyazaki N, Bartlett EL, Sangha S* (2024). Suppressing fear in the presence of a safety cue requires infralimbic cortical signaling to central amygdala. Neuropsychopharmacology, 49: 359-367.
Fitzgerald J*, Webb EK, Sangha S (2023). Psychological and Physiological Correlates of Stimulus Discrimination in Adults. Psychophysiology, e14327.
Ng K, Sangha S* (2023). Encoding of conditioned inhibitors of fear in the infralimbic cortex. Cerebral Cortex 33: 5658-5670
Hackleman A, Ibrahim M, Shim K, Sangha S* (2023). Interaction of stress and alcohol on discriminating fear from safety and reward in male and female rats. Psychopharmacology 240: 609-621
What we do
Clinical disorders arising from maladaptive emotion regulation present a large burden on society worldwide and many of these disorders show comorbidity, for example, addiction with anxiety disorders. Even though there has been much research on reward and fear processing, the majority of studies have been conducted in parallel, investigating the neuronal circuitries separately. Our lab uses a behavioral paradigm designed to assess how safety cues can regulate fear and reward seeking behaviors in male and female rats. We hope by investigating how safety, fear and reward circuits integrate their functions to influence behavior, we will be able to better understand and treat disorders resulting from maladaptive emotion regulation.
Sangha Lab
Recent interview with Dr. Sangha by Psychopharmacology regarding the lab's 2023 paper on alcohol and stress effects in safety discrimination (Hackleman et al 2023).
Science can be hard. It's important to have fun.
Susan Sangha, PhD
Associate Professor of Psychiatry
Indiana University School of Medicine
Stark Neuroscience Research Institute
Department of Psychiatry, Indiana University School of Medicine
Stark Neuroscience Research Institute
razzle dazzle provided by M. Pollock